| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799255 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2013 | 14 Pages |
Abstract
⺠Histone modifications influence chromatin organization during transcription elongation. ⺠Histone chaperones and H2B ubiquitination maintain nucleosome levels over gene bodies. ⺠Disruption of histone H3K36 methylation leads to increased histone exchange and altered, hyperacetylated chromatin. ⺠Perturbation of chromatin structure over gene bodies exposes cryptic promoters. ⺠Cryptic transcripts are polyadenylated and even translated - their function is unclear though.
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Authors
Michaela Smolle, Jerry L. Workman,