| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799269 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2013 | 7 Pages |
Abstract
⺠HNF-4 plays a crucial role in the development and maintenance the liver phenotype. ⺠Specific miRNAs down-regulate HNF-4 expression by targeting 3â²-UTR of HNF-4 mRNA. ⺠The miRNA dependent regulation affects the transactivation of HNF-4 target genes. ⺠The regulatory mechanism of miRNAs may have important impacts on liver phenotype.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Zhongyan Wang, Peter A. Burke,