| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799285 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2012 | 8 Pages |
Abstract
⺠Two simple and consecutive chemical reactions are catalyzed co-trancriptionally by the spliceosome, a large macromolecular complex. ⺠The spliceosome is essential for generating mature mRNA. ⺠The cell takes advantage of this to generate different amounts and isoforms of mRNAs, according to its needs. ⺠In yeast, control of pre-mRNA splicing of critical genes allows the cell to affect all the pathways in gene expression. ⺠The spliceosome can be both the sensor and controller to fine tune genetic output.
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Authors
Tracy L. Johnson, Josep Vilardell,