Article ID Journal Published Year Pages File Type
10799289 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2012 15 Pages PDF
Abstract
►Nuclear mRNA export begins with assembly of an export-competent mRNP in the nucleus. ►Export-competent mRNPs diffuse back-and-forth through nuclear pores. ►Dbp5 removes export factors from mRNPs at the pore's cytoplasmic face, preventing return to the nucleus. ►TREX and TREX-2 link export-competent mRNPs assembly to earlier gene expression pathway steps. ►Emerging structural information is generating a molecular understanding of these processes.
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