Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799302 | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 2008 | 10 Pages |
Abstract
The 3â²-to-5â² exonucleolytic decay and processing of a variety of RNAs is an essential feature of RNA metabolism in all cells. The 3â²-5â² exonucleases, and in particular the exosome, are involved in a large number of pathways from 3â² processing of rRNA, snRNA and snoRNA, to decay of mRNAs and mRNA surveillance. The potent enzymes performing these reactions are regulated to prevent processing of inappropriate substrates whilst mature RNA molecules exhibit several attributes that enable them to evade 3â²-5â² attack. How does an enzyme perform such selective activities on different substrates? The goal of this review is to provide an overview and perspective of available data on the underlying principles for the recognition of RNA substrates by 3â²-to-5â² exonucleases.
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Authors
Hend Ibrahim, Jeffrey Wilusz, Carol J. Wilusz,