| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799692 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 63 Pages |
Abstract
MAPKs are essential for various cellular responses to osmotic stress; thus, the identification of the upstream regulators of MAPK pathways will provide valuable clues regarding the cellular osmosensing mechanism, which remains elusive in mammals. The elucidation of in vivo MAPK functions is also important because osmotic stress in physiological and pathophysiological conditions often results from changes in the intracellular osmolality. These studies potentially contribute to the establishment of therapeutic strategies against diseases that accompany osmotic perturbation.
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Authors
Xiangyu Zhou, Isao Naguro, Hidenori Ichijo, Kengo Watanabe,