| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799699 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 14 Pages |
Abstract
We demonstrate that γ-radiation induces the generation of ACS in physiological solutions. SDG treatment scavenged ACS and prevented ACS-induced DNA damage and chlorination of 2-aminopurine. This study identified a novel and unique mechanism of SDG radioprotection, through ACS scavenging, and supports the potential usefulness of SDG as a radioprotector and mitigator for radiation exposure as part of cancer therapy or accidental exposure.
Keywords
Cl2ClO−APFhpfActive chlorine speciesHOClSDGACSRFUsecoisolariciresinol diglucoside2-APHypochlorite ionPBS2-aminopurineCl−Supercoiled DNAROSγ-RadiationHydrogen peroxideChlorine atomChlorine atomshypochlorous acidanalysis of varianceANOVAMitigationDNA fragmentationRadioprotectionstandard error of the meanRadicalsHydroxyl radicalPhosphate-buffered salineSEMH2O2Relative Fluorescence UnitsTaurine chloramineChlorineReactive oxygen species•OH
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Authors
Om P. Mishra, Anatoliy V. Popov, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou,