| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799729 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 50 Pages |
Abstract
Our study reports, for the first time, that iron, at concentration found in overloaded patient sera, stimulates the growth of BM-MSCs, the BM multipotent stromal cell component. Moreover, iron modulates the physiological differentiation of these cells, affecting bone turnover and remodeling.
Keywords
pNPPqPCRDCF-DAFACTFRTransferrinhBM-MSCsSACARSstandard medium2′,7′-dichlorofluorescein diacetatepara-nitrophenyl phosphateQuantitative PCRROSAlkaline phosphataseIronFerric Ammonium CitrateOsteocalcinOsteogenesisMesenchymal stromal cellsOsteogenic mediumMineralizationIron overloadReactive oxygen speciestransferrin receptor
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Authors
Adriana Borriello, Ilaria Caldarelli, Maria Carmela Speranza, Saverio Scianguetta, Annunziata Tramontano, Debora Bencivenga, Emanuela Stampone, Aide Negri, Bruno Nobili, Franco Locatelli, Silverio Perrotta, Adriana Oliva, Fulvio Della Ragione,