Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799761 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 36 Pages |
Abstract
To evaluate this, we collected blood plasma samples of five healthy donors over a time period of up to six years (min. 1.5Â years). The plasma N-glycome was analyzed by xCGE-LIF, to investigate the intra-individual N-glycome variability over time. It is shown, that the plasma N-glycome of an individual is remarkably stable over a period of several years, and that observed small longitudinal changes are independent from seasons, but significantly correlated with lifestyle and environmental factors. Thus, the potential of future longitudinal biomarker discovery studies could be demonstrated, which is a further step towards personalized diagnostics. This article is part of a Special Issue entitled “Glycans in personalised medicine” Guest Editor: Professor Gordan Lauc.
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Authors
René Hennig, Samanta Cajic, Matthias Borowiak, Marcus Hoffmann, Robert Kottler, Udo Reichl, Erdmann Rapp,