| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799764 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 50 Pages |
Abstract
Deletion of N-glycans can enhance viral immunogenicity. The selected CpG-E1E2-M4 mutant is a novel potential HCV DNA vaccine that elicits enhanced CD4+ Th1 and CD8+ T cell responses and neutralizing antibody production against HCV infection. This article is part of a Special Issue entitled "Glycans in personalised medicine" Guest Editor: Professor Gordan Lauc.
Keywords
ODNOligodeoxynucleotidesHCVppHCVccCell culture-derived HCVELISPOTCTLAPCSFCEC50RT-qPCRMOIN-glycosylationEnzyme-linked immunospot assayinterferonIFNinterleukinNeutralizationantigen presenting cellhalf-maximal effective concentrationcytotoxic T lymphocytespot forming cellsHCVHepatitis C virusDNA vaccineCellular immune responsemultiplicity of infection
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Authors
Yushan Ren, Yuan-Qin Min, Min Liu, Lianli Chi, Ping Zhao, Xiao-Lian Zhang,