| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10799829 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 10 Pages |
Abstract
These data demonstrate that treatment with imipramine, which is a routine in counteracting depressive disorders, enhances the phosphorylation of PYK2, a non-receptor kinase instrumental in promoting synaptic plasticity. This effect documents as yet not considered target in the mechanism of imipramine action.
Keywords
ECMRTKpCREBPYK2PKCGPCRα1-ARPSA-NCAMCaMKIIFAKCa2 +/calmodulin-dependent protein kinase IIERK1/2G-protein coupled receptorMAPKproline-rich tyrosine kinase 2long-term potentiationLTPAntidepressant drugdiacylglycerolDAGExtracellular matrixG proteinsProtein kinase Cmitogen-activated protein kinasefocal adhesion kinaseextracellular signal-regulated kinases 1 and 2α1-Adrenergic receptorReceptor Tyrosine Kinase
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Authors
Teresa Zalewska, Adam Bielawski, Luiza Stanaszek, Krzysztof Wieczerzak, MaÅgorzata Ziemka-NaÅÄcz, Irena Nalepa,