Article ID Journal Published Year Pages File Type
10799851 Biochimica et Biophysica Acta (BBA) - General Subjects 2016 33 Pages PDF
Abstract
As tumors express inducible nitric oxide synthase and generate significant amounts of NO, modulation of topo II functions by NO/NO-derived species could render tumors resistant to certain topo II-poisons in the clinic.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Nitric oxide inhibits topoisomerase II activity and induces resistance to topoisomerase II-poisons in human tumor cells
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