Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799927 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2015 | 11 Pages |
Abstract
Protein N- and O-glycosylation can modulate ion channel gating simultaneously. These data also suggest that environmental, metabolic, and/or congenital changes in glycosylation that impact sugar substrate levels, could lead, potentially, to changes in Nav sialylation and gating that would modulate AP waveforms and conduction.
Keywords
SSAN-acetylgalactosamineGalNAcVoltage-gated Na+ channelsHERGSSIO-GlycosylationGlcNAcN-glycosylationSialic acidsNeuraminic acidChoChinese Hamster OvaryIon channel gatingInactivationNavN-acetylglucosamineapparent molecular weightaction potentialsVoltage-gated K+ channelVoltage-gated ion channelsGalGalactose
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Authors
Andrew R. Ednie, Jean M. Harper, Eric S. Bennett,