Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts

Article ID	Journal	Published Year	Pages	File Type
10799935	Biochimica et Biophysica Acta (BBA) - General Subjects	2015	10 Pages	PDF

Abstract

The results of this study suggest that PsA is sufficient to overcome multidrug-resistant cancer via SIRT1-mediated autophagy in MCF-7/adr breast cancer cells, indicating that PsA has therapeutic potential for clinical use.

Keywords

ATG damage-regulated autophagy modulator MCF-7/adr DRAM Dnmt LC3 AMPK HDAC DOX AMP-activated protein kinase DNA methyltransferase Bax Doxorubicin histone deacetylase Bcl-2-associated X protein microtubule-associated protein 1 light chain 3 autophagy-related gene

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts

Authors

Tae Hyung Kim, Hyuk Soon Kim, Yoon Jong Kang, Sungpil Yoon, Jaewon Lee, Wahn Soo Choi, Jee H. Jung, Hyung Sik Kim,