Article ID Journal Published Year Pages File Type
10799956 Biochimica et Biophysica Acta (BBA) - General Subjects 2015 12 Pages PDF
Abstract
A series of dihydroindolizino indole derivatives were synthesized and their antitumor activity, ability to selectively interact and stabilize G-quadruplex DNA were studied. Results indicate that 4-cyanophenyl linked derivative (DHII-4CPh) is superior in all aspects. It is closely followed by thiophen-2-yl (DHII-TPh) and 3-methyl-1-phenyl-1H-pyrazol-4-yl (DHII-MPhPy) linked derivatives.219
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells
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