Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10799958 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2015 | 9 Pages |
Abstract
On the basis of our mass-spectrometry analysis supported by the bacterial two-hybrid assay and biophysical analyses, a unique pathway of the parasite stalk assembling has been proposed. We suggest that the absence of P1/P2 heterodimer, and the formation of a stable pentamer in the presence of all three proteins, indicate a one-step formation to be the main pathway for the vital ribosomal stalk assembly, whereas the P2 homo-oligomer may represent an off-pathway product with physiologically important nonribosomal role.
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Authors
Leszek Wawiórka, Dawid Krokowski, Yuliya Gordiyenko, Daniel Krowarsch, Carol V. Robinson, Ishag Adam, Nikodem Grankowski, Marek Tchórzewski,