Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia

Article ID	Journal	Published Year	Pages	File Type
10800019	Biochimica et Biophysica Acta (BBA) - General Subjects	2015	12 Pages	PDF

Abstract

These findings demonstrate the significance of redox signaling in cellular pathways. Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders.

Keywords

PBS GRx PRX STR thioredoxins TrxR CCA Trx ROS Perinatal asphyxia Striatum Common carotid artery occlusion Reoxygenation thioredoxin reductase Enzyme-linked immunosorbent assay ELISA standard error of the mean CNS postnatal day 7 Cer central nervous system common carotid artery phosphate buffer saline Cerebellum SEM HIP Hippocampus Hypoxia Peroxiredoxins Glutaredoxins Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Thioredoxin 1 and glutaredoxin 2 contribute to maintain the phenotype and integrity of neurons following perinatal asphyxia

Authors

Juan Ignacio Romero, Eva-Maria Hanschmann, Manuela Gellert, Susanne Eitner, Mariana Inés Holubiec, Eduardo Blanco-Calvo, Christopher Horst Lillig, Francisco Capani,