| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800023 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2015 | 7 Pages |
Abstract
The C1-inh polymers might play a role in the pathophysiology of HAE, but several diseases are characterized by the presence of serpin polymers. The role of serpin polymers has so far remained elusive, but our results indicate that such polymers can play a role as inflammatory mediators through the FXII-dependent KKS.
Keywords
FXIIPAGECPKHRPKKSCPDAcitrate phosphate dextrose adenineC1-INHPVDFmAbSDSFXIIaRCLPrekallikreinPBSHMWKBSAdBSAo/nSERPINopdbovine serum albuminMonoclonal antibodyHereditary angioedemapolyacrylamide gel electrophoresisSerine protease inhibitorHAEReactive center loopRoom temperaturesodium dodecyl sulfateKallikrein-kinin systemkallikrein–kinin systemCoagulation factor XIIPhosphate buffered salineWestern blotHorseradish peroxidasePolyvinylidene fluoridePolymerizationoptical densityhigh molecular weight kininogenovernight
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Authors
Daniel Elenius Madsen, Johannes Jakobsen Sidelmann, Daniel Biltoft, Jørgen Gram, Soren Hansen,