| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800086 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2014 | 12 Pages |
Abstract
Altogether, these data suggest that CS initiates EMT through Rac1/Smad2 and Rac1/PI3K/Akt signaling pathway. Our data provide new insights into the fundamental basis of EMT and suggest a possible new course of therapy for COPD and lung cancer.
Keywords
PI3KATNAALK5Rac1ERKMMP-9NSCJnkTGF-β1α-SMACSEc-Jun N-terminal kinasesMAPKPKB, Protein kinase BAktα-smooth muscle actinCOPDChronic obstructive pulmonary diseaseTransforming growth factor β1EMTcigarette smoke extractPhosphatidylinositol 3-kinasePulmonary fibrosismatrix metalloproteinases-9extracellular regulated protein kinasesmitogen-activated protein kinasesEpithelial–mesenchymal transition
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Authors
Hui-juan Shen, Yan-hong Sun, Shui-juan Zhang, Jun-xia Jiang, Xin-wei Dong, Yong-liang Jia, Jian Shen, Yan Guan, Lin-hui Zhang, Fen-fen Li, Xi-xi Lin, Xi-mei Wu, Qiang-min Xie, Xiao-feng Yan,