| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800195 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2014 | 8 Pages |
Abstract
Dynamic changes in the regulation of mitochondrial metabolism may have far-reaching consequences for many diseases, and despite promising initial findings in knockout animals and cell models, the role of the mitochondrial sirtuins requires further exploration in this context. This article is part of a Special Issue entitled Frontiers of mitochondrial research.
Keywords
MEFssuccinate dehydrogenase subunit APGC1αLCADPDHsdhAlysine acylationCPT1Long chain acyl-CoA dehydrogenaseCPS1SOD2MCDMCADMDHHIF-1αGDHPTMIDH2human cervical carcinoma cellsNADPHTCAOTCFOXO3aHMGCS2ADPsirtuinMPTPmalonyl-CoA decarboxylaseNAD+ROSadenosine diphosphatepost-translational modificationmitochondrial permeability transition poreisocitrate dehydrogenase 2Superoxide dismutase 2hypoxia inducible factor 1αmurine embryonic fibroblastsMitochondrial metabolismcalorie restrictionmalate dehydrogenaseNDUFA9nicotinamide adenine dinucleotidenicotinamide adenine dinucleotide phosphate (reduced)peroxisome proliferator-activated receptor gamma coactivator 1αpyruvate dehydrogenasetricarboxylic acid cycleCarbamoyl phosphate synthetase 1Carnitine palmitoyltransferase IHelaglutamate dehydrogenaseReactive oxygen species
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Authors
Brenna Osborne, Gregory J. Cooney, Nigel Turner,