Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

Article ID	Journal	Published Year	Pages	File Type
10800198	Biochimica et Biophysica Acta (BBA) - General Subjects	2014	14 Pages	PDF

Abstract

Elucidation of the adaptive mechanism involved in AMPK activation cascades would lead us to gain a deeper insight into the crosstalk between mitochondria and the nucleus in affected tissue cells from patients with mitochondrial diseases. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research.

Keywords

G6PD PGC-1α OXPHOS MELAS GPX GSH PPP NADPH CPEO MERRF Permeability transition pores CaMKs AMPK Sirt1 CREB AMP-activated protein kinase Mitochondrial DNA Mn-SOD NAD+PTPs ROS Hydrogen peroxide Antioxidant enzyme mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes Autophagy Metabolic reprogramming Mitochondrial disease Oxidative stress silent information regulator 1 mtDNA manganese-dependent superoxide dismutase Myoclonic epilepsy with ragged-red fibers FoxO Oxidative phosphorylation pentose phosphate pathway nicotinamide adenine dinucleotide H2O2 peroxisome proliferator-activated receptor gamma coactivator 1α cAMP-responsive element-binding protein Chronic progressive external ophthalmoplegia reduced nicotinamide adenine dinucleotide phosphate reduced glutathione glutathione peroxidase glucose 6-phosphate dehydrogenase Reactive oxygen species