Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10800204 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2014 | 11 Pages |
Abstract
Many disease phenotypes associated with OXPHOS malfunction might be determined by the outcomes of mitochondrial-nuclear interactions, and by the evolutionary forces that historically shaped mitochondrial DNA (mtDNA) sequences. Concepts and results drawn from the evolutionary sciences can have broad, but currently under-utilized, applicability to the medical sciences and provide new insights into understanding the complex genetics of mitochondrial disease. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research.
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Authors
Damian K. Dowling,