The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

Article ID	Journal	Published Year	Pages	File Type
10800284	Biochimica et Biophysica Acta (BBA) - General Subjects	2014	10 Pages	PDF

Abstract

This study sheds light on how different structurally closely related VEGFR2 ligands bind to and signal via VEGFR2/Nrp complex to induce angiogenesis and vascular permeability. The knowledge of this study could be used for designing VEGFR2/Nrp ligands with improved therapeutic properties.

Keywords

HEK293T cells HSP27 NRP PlGF HUVECS VEGFR2 human embryonic kidney 293T cells PLCγ TSAd HSPGs VE-cadherin Angiogenesis hexahistidine tag His-tag porcine aortic endothelial cells Human umbilical vein endothelial cells placenta growth factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)phospholipase Cγ Receptor activation Neuropilin Heat shock protein 27 heparan sulfate proteoglycans vascular endothelial cadherin VEGF receptor 2

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

Authors

Tiina Nieminen, Pyry I. Toivanen, Nina Rintanen, Tommi Heikura, Suvi Jauhiainen, Kari J. Airenne, Kari Alitalo, Varpu Marjomäki, Seppo Ylä-Herttuala,