| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800358 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2014 | 10 Pages |
Abstract
The 1-benzyl-3-ketoindole derivatives 7-9 acting as positive or negative allosteric modulators of human A2B AR represent new pharmacological tools useful for the development of therapeutic agents to treat pathological conditions related to an altered functionality of A2B AR.
Keywords
DMEMRo 20-1724[3H]NECABAY 60-6583A2B adenosine receptorGPCR4-dimethylaminopyridineDMAP3′,5′-cyclic adenosine monophosphatecAMPDulbecco's modified Eagle Medium[35S]GTPγSadenosine deaminaseChoChinese Hamster OvaryLigand–receptor interactionPositive allosteric modulatorsNegative allosteric modulatorsADAAdenosine receptorG protein-coupled receptor
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Authors
Maria Letizia Trincavelli, Chiara Giacomelli, Simona Daniele, Sabrina Taliani, Barbara Cosimelli, Sonia Laneri, Elda Severi, Elisabetta Barresi, Isabella Pugliesi, Giovanni Greco, Ettore Novellino, Federico Da Settimo, Claudia Martini,