| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800427 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 18 Pages |
Abstract
⺠Trypanosomes posses a unique thiol-redox system centered on trypanothione, a bis-glutathionyl conjugate of spermidine. ⺠Trypanothione system sustains cellular functions that in higher eukaryotes rely on glutathione or thioredoxin systems. ⺠Trypanothione-dependent redox-metabolism is the Achilles' heel of these ancient and deadly parasites.
Keywords
Ornithine decarboxylaseGSSGLMWCBSDNICGSNOGSPTrxRCGLRNRHEDTrxGSPsODCPRXGRxTXNNitrosoglutathioneTs2Monothiol glutaredoxinhydroxyethyl disulfideγ-glutamyl-cysteine synthetaseRTSGSHGSTGPXTryRSPDMSRLIPSATFe–SSPSMSTISCDMPO3-mercaptopyruvate sulfurtransferasecystathionine-γ-lyaseT(SH)2AntioxidantSerine acetyltransferaseSpermidineSpermidine synthasethioredoxin reductaseTryparedoxintrypanothione reductaseTrypanothione synthetaseTrypanosomeEPRElectron paramagnetic resonancethioredoxintrypanothione disulfideFree radicalRedoxRibonucleotide reductaseTrySCysteine synthasecystathionine-β-synthasemethionine sulfoxide reductaselow molecular weightPeroxiredoxinPolyamineDinitrosyl iron complexChapreduced glutathioneglutathione-S-transferaseglutathione disulfideglutathione synthetaseglutathione peroxidaseGlutaredoxin
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Authors
Bruno Manta, Marcelo Comini, Andrea Medeiros, MartÃn Hugo, Madia Trujillo, Rafael Radi,