Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Article ID	Journal	Published Year	Pages	File Type
10800509	Biochimica et Biophysica Acta (BBA) - General Subjects	2013	13 Pages	PDF

Abstract

Compared to the commercial lipoplex approach, oligodeoxyribonucleotide conjugation with C28 dual lipid modification seems to be promising to improve oligonucleotide delivery in mammalian cells.

Keywords

MLV Supported planar bilayer PFA CpG ODN TOF GUV TLC ACN SPB TEAA GMFI DOPC ESM oligodeoxyribonucleotide FBS DMEM CHOL PBS AFM Dulbecco's modified Eagle's medium Triethylammonium acetate Acetonitrile egg sphingomyelin Time-of-Flight fetal bovine serum geometric mean fluorescence intensity Controlled-pore glass Giant unilamellar vesicle SUV Liquid-ordered Liquid-disordered Loc Phosphate-buffered saline atomic force microscopy paraformaldehyde Multilamellar vesicle thin-layer chromatography cholesterol Small unilamellar vesicle

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

Authors

Begoña Ugarte-Uribe, Santiago Grijalvo, Jon V. Busto, César MartÃn, Ramón Eritja, Félix M. Goñi, Itziar Alkorta,