Article ID Journal Published Year Pages File Type
10800546 Biochimica et Biophysica Acta (BBA) - General Subjects 2013 9 Pages PDF
Abstract
In contrast to warfarin IC50 values determined in previous studies, warfarin inhibition expressed as Ki can now be compared between studies, even when the specific DTT-driven VKOR assay conditions differ. This implies that warfarin inhibition reported for wild-type and variant VKORC1 enzymes from previous reports should be reassessed and new determinations of Ki are required to accurately report and compare in vitro warfarin inhibition results.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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