Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10800546 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 9 Pages |
Abstract
In contrast to warfarin IC50 values determined in previous studies, warfarin inhibition expressed as Ki can now be compared between studies, even when the specific DTT-driven VKOR assay conditions differ. This implies that warfarin inhibition reported for wild-type and variant VKORC1 enzymes from previous reports should be reassessed and new determinations of Ki are required to accurately report and compare in vitro warfarin inhibition results.
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Authors
Carville G. Bevans, Christoph Krettler, Christoph Reinhart, Hélène Tran, Katja KoÃmann, Matthias Watzka, Johannes Oldenburg,