Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10800566 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 12 Pages |
Abstract
⺠first site-specific 11C-labeling of AnxA5 in the C-terminus for PET studies of induced cell death ⺠first use of a size-matched protein to estimate non-specific uptake and retention ⺠use of Sel-tag to identically label both proteins, with retained Ca-dependent binding of AnxA5-ST to apoptotic cells ⺠comparable pharmacokinetics of AnxA5 and its control except in the kidney and urine ⺠uptake of AnxA5 increased but control protein decreased in induced cell death.
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Authors
Qing Cheng, Li Lu, Jonas Grafström, Maria Hägg Olofsson, Jan-Olov Thorell, Erik Samén, Katarina Johansson, Hanna-Stina Ahlzén, Stig Linder, Elias S.J. Arnér, Sharon Stone-Elander,