| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800567 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 9 Pages |
Abstract
⺠PI3K/AKT pathway is highly conserved in growth factor signal transduction. ⺠RmAKT ORF was phylogenetically and functionally analyzed. ⺠AKT inhibition or gene silencing reduces glycogen and viability of BME26 cells. ⺠GSK3 inhibition and gene silencing cause opposing effects. ⺠AKT/GSK3 signaling axis may be present during all tick stages.
Keywords
dsRNAPI3KIGFFBSISPRTKORFIC50Phosphatidylinositol 3-OH kinaseGSK3DMSOMTTdouble-stranded RNARNAiAktCell survivalrapid amplification of cDNA endsTick cell lineGene silencingDimethyl sulfoxidefetal bovine serumInsulin-like growth factoropen reading frameGlycogen metabolismRaceprotein kinase Bnegative controlglycogen synthase kinase 3Receptor Tyrosine Kinase
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Authors
Leonardo Araujo de Abreu, Christiano Calixto, Camila Fernanda Waltero, Bárbara Pitta Della Noce, Naftaly Wang'ombe Githaka, Adriana Seixas, LuÃs Fernando Parizi, Satoru Konnai, Itabajara Jr., Kazuhiko Ohashi, Carlos Logullo,