IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A-IGFBP interaction sites

Article ID	Journal	Published Year	Pages	File Type
10800579	Biochimica et Biophysica Acta (BBA) - General Subjects	2013	27 Pages	PDF

Abstract

âº Acidic residues of PAPP-A are required for substrate cleavage. âº Structural calcium ions are suggested to be implicated in interaction with IGFBPs. âº IGF-IGFBP interaction determines protease-substrate binding. âº The central and the C-terminal domains of IGFBPs mediate IGF dependent proteolysis.

Keywords

IGF LNR CCP IGFBP PAPP-A Insulin-like growth factor Proteolysis pregnancy-associated plasma protein-A IGF-binding protein complement control protein

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A-IGFBP interaction sites

Authors

Ervinas Gaidamauskas, Claus Gyrup, Henning B. Boldt, Vivien R. Schack, Michael T. Overgaard, Lisbeth S. Laursen, Claus Oxvig,