| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800585 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 7 Pages |
Abstract
⺠p38α, an inflammatory MAP kinase plays an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). ⺠A tetrapeptide, VWCS was designed and synthesized against the ATP binding site of the p38 α kinase. ⺠The peptide VWCS showed an efficient interaction with the ATP binding site as determined by the KD and IC50 value. ⺠VWCS also exhibited anti-cancerous activity and induced apoptosis.
Keywords
DLSMKKKHBTUHTVSactivated transcription factorHNSCCTFANPPATFIPTGPBSDMF2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphateMAPKMAPK kinaseMKKRPcTrifluoro acetic acidStandard PrecisionExtra Precisiondimethyl formamidephosphate buffer salineLuria-BertaniMHCDynamic Light Scatteringmitogen activated protein kinaseHead and neck squamous cell carcinoma
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Authors
Kamaldeep Gill, Abhay K. Singh, Vaishali Kapoor, Lokesh Nigam, Rahul Kumar, Prasida Holla, Satya N. Das, Savita Yadav, Naidu Subbarao, Bidhu K. Mohanti, Sharmistha Dey,