Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10800588 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 8 Pages |
Abstract
⺠10 p53 variants encoded by mutated TP53 in breast cancers were characterised. ⺠Each tumour was characterised for response to anthracycline or mitomycin therapy. ⺠All mutants bound wild-type p53, potentially acting in a dominant negative manner. ⺠All mutants showed reduced induction of apoptosis/senescence ⺠P53 mutations both within and outside the L2/L3 domains may cause treatment failure.
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Authors
Elisabet O. Berge, Johanna Huun, Johan R. Lillehaug, Per E. Lønning, Stian Knappskog,