| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800591 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 7 Pages |
Abstract
⺠Small GTPase Ran decreases in normal mammalian cells in a passage-dependent manner. ⺠siRNA-mediated depletion of Ran causes cellular senescence in human fibroblasts. ⺠Ran-depletion causes nuclear accumulation of importin α. ⺠Nuclear accumulation of importin α occurs in old cells and cells lacking CAS. ⺠CAS-depleted cells also exhibit cellular senescence.
Keywords
HDFMEFCASMnSODSA-β-galRas-related nuclear proteinHGPSSmall interfering RNAROSsiRNAsenescence-associated β-galactosidaseCell fate determinationHutchinson–Gilford progeria syndromemanganese superoxide dismutaseRånhuman diploid fibroblastmouse embryonic fibroblastImportin αCellular ageingCellular senescenceReactive oxygen species
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Authors
Masahiro Nagai, Yoshihiro Yoneda,