| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800593 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 9 Pages |
Abstract
⺠We investigated the contribution of NO during the differentiation of human CD34+HSCs toward i-DCs. ⺠We found a peak of NO production at the time of stem cell commitment. ⺠The inhibition of NOS isoforms impaired the differentiation process of i-DCs from CD34+HSCs. ⺠The depletion of NO preserved the stem cell in a commitment stage for a long time in culture. ⺠The depletion of NO retrieved the clonogenic ability of cytokine induced CD34+HSCs.
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Authors
Roberto Tiribuzi, Lucia Crispoltoni, Francesco Tartacca, Antonio Orlacchio, Sabata Martino, Carlo Alberto Palmerini, Aldo Orlacchio,