The Global Sequence Signature algorithm unveils a structural network surrounding heavy chain CDR3 loop in Camelidae variable domains

Article ID	Journal	Published Year	Pages	File Type
10800620	Biochimica et Biophysica Acta (BBA) - General Subjects	2013	9 Pages	PDF

Abstract

âº Identification of a Camelidae antibody signature outside of classical hallmarks âº The programme identifies networks of coevolving residues related to sequence properties. âº The length of the CDR3 loop correlates with the nature of its surrounding residues. âº The algorithm constitutes a new analysis tool for protein and antibody design.

Keywords

CDR MSA SCA MDS GSS VHH PCA immunoglobulin G Statistical coupling analysis Principal component analysis multiple sequence alignment light chain variable domain Multidimensional scaling complementarity determining region Co-evolution Framework