| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800627 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 10 Pages |
Abstract
⺠Twelve peptides were synthesized based on two antimicrobial venom components. ⺠Hadrurin and vejovine were used to design novel active but shorter peptides (18mers). ⺠Four of them showed good antimicrobial activity at micromolar range concentration. ⺠A variety of bacteria resistant to antibiotics were sensitive to these peptides. ⺠Procaryotic microorganisms were better targets than eukaryotic cells.
Keywords
CLSIPlasmodium bergheiMTSATCCHOBtRP-HPLCTFAPoPCFMOCMICAMPsHBTUPOPGDMFDMEMCFUMDR1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol)2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphateDulbecco's modified Eagle's mediumN,N-dimethylformamideN,N-diisopropylethylamineSUVsl-α-phosphatidylcholineAntibioticTrifluoroacetic acidCalcein releaseMinimal inhibitory concentrationcircular dichroismCell viabilityAmerican Type Culture Collectionmulti-drug resistantClinical and Laboratory Standards InstituteDIPEAcolony forming unitsAntimicrobial peptideAntimicrobial peptidesreverse-phase high-performance liquid chromatographysmall unilamellar vesicles
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Authors
Lorenzo Sánchez-Vásquez, Jesus Silva-Sanchez, Juana Maria Jiménez-Vargas, Adela RodrÃguez-Romero, Carlos Muñoz-Garay, Maria C. RodrÃguez, Georgina B. Gurrola, Lourival D. Possani,