| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800629 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 7 Pages |
Abstract
⺠Intralipid targets the liver Kupffer cells and blunts nanoparticle clearance. ⺠Intralipid results in an ~ 50% decrease in liver uptake of USPIO and MPIO particles. ⺠Intralipid produces an ~ 3-fold increase in blood half-life of the particles. ⺠Intralipid causes a 2 to 5-fold increase in labeling efficiency of blood monocytes. ⺠Nanoparticles can target more diverse sites or organs, other than the liver.
Keywords
PBSFDAMPIOFITCIntralipidppmRESUSPIOTransverse relaxivityMRIpart per millionBrown NorwayMagnetic resonance imagingFood and Drug AdministrationReticuloendothelial systeminductively coupled plasma-mass spectrometryICP-MSfluorescein isothiocyanateNanoparticlestransverse relaxation ratepolyethylene glycolPEG
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Authors
Li Liu, T. Kevin Hitchens, Qing Ye, Yijen Wu, Brent Barbe, Devin E. Prior, Wendy F. Li, Fang-Cheng Yeh, Lesley M. Foley, Daniel J. Bain, Chien Ho,