| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800631 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 8 Pages |
Abstract
⺠Brain accumulation of triphenylphosphonium cations is decreased by ABC transporters. ⺠ABC-transporter inactivation increases brain uptake of triphenylphosphonium cations. ⺠Bypassing ABC transporters may increase the effectiveness of mitochondrial therapies.
Keywords
TPPTPMPTPBMitoQMPTPMDR1Bcrp1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineABC proteinsROSCSATetraphenylborateABC transportersintra peritonealintra venousBlood–brain barrierBBBcyclosporin AmethyltriphenylphosphoniumMitochondriabreast cancer resistance proteinTriphenylphosphonium cationLipophilic cationReactive oxygen species
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Authors
Carolyn M. Porteous, David K. Menon, Franklin I. Aigbirhio, Robin A.J. Smith, Michael P. Murphy,