| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800640 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 11 Pages |
Abstract
⺠An inbred prematurely aging OXYS and control Wistar rats were used. ⺠OXYS is characterized by high sensitivity to oxidative stress, learning and memory deterioration. ⺠We have analyzed base lesion 8-oxoguanine in different brain regions of these rats. ⺠8-OxoG increased in neurons, nestin- and (GFAP)-positive cells of hippocampus and frontal cortex. ⺠OXYS rats demonstrate significantly higher levels of oxidative brain DNA damage than Wistar rats.
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Authors
Evgeniya A. Sattarova, Olga I. Sinitsyna, Elena A. Vasyunina, Alexander B. Duzhak, Nataliya G. Kolosova, Dmitry O. Zharkov, Georgy A. Nevinsky,