Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells

► Chronic hypoxia (CH) affects levels of neuronal markers and reduces proliferation of PC12 cells. ► CH alters mitochondrial shape and turnover and leads to cytochrome c increase. ► Reduction in O2 consumption rate is coupled with activated AMPK and glycolysis. ► Glycogen production and resistance to O2 and glucose deprivation in hypoxic cells are increased. ► Unlike HIF-1, HIF-2 no longer regulates response to acute O2 deprivation in CH cells.