| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800649 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 8 Pages |
Abstract
⺠Enzymes MVK, PMK, MDD, and FPPS, play regulatory roles in mevalonate pathway. ⺠Two fluorescent bisphosphonates were synthesized as multi-enzyme inhibitors. ⺠These two compounds had potent inhibition to all four enzymes. ⺠Kinetic and molecular modeling studies of these two compounds were carried out. ⺠Fluorescence microscopy indicated that the compounds could get into cancer cells.
Keywords
FPPPMKTsClMVKFPPSIPPMDDGPP3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide3-hydroxy-3-methylglutaryl-CoA reductaseHMG-CoA reductaseMTTisopentenyl diphosphateBisphosphonatefarnesyl pyrophosphatefarnesyl pyrophosphate synthasePhosphomevalonate kinasenitrogen-containing bisphosphonatesGeranyl diphosphateMevalonate Kinase
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Authors
Jinbo Gao, Jinggong Liu, Yongge Qiu, Xiusheng Chu, Yuqin Qiao, Ding Li,