| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800652 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 8 Pages |
Abstract
⺠The expression of InsC96Y activates the ASK1-p38 pathway in à cell. ⺠Deletion of ASK1 mitigates InsC96Y-induced à cell death. ⺠Inhibition of p38 suppresses InsC96Y-induced à cell death. ⺠Deletion of ASK1 delays the onset of diabetes in Akita mice.
Keywords
UPRIns2WRSCarbonic anhydrase VICA6Akita mouseASK1ATF6IRE1p38DMEMFBSERADFITCMEFDulbecco's modified Eagle's mediumMTTinositol-requiring enzyme 1ER stressDiabetesER-Associated DegradationTUNELCHOPApoptosisfetal bovine serumendoplasmic reticulumactivating transcription factor 6fluorescein isothiocyanatemouse embryonic fibroblastsmapUnfolded protein responsemitogen-activated proteinCCAAT-enhancer-binding protein homologous proteinprotein kinase RNA-like ER kinasePERKapoptosis signal-regulating kinase 1
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Authors
Kiyoshi Yamaguchi, Kohsuke Takeda, Hisae Kadowaki, Ikumi Ueda, Yoshio Namba, Yasuyoshi Ouchi, Hideki Nishitoh, Hidenori Ichijo,