| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800668 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 12 Pages |
Abstract
⺠The ER contains GPx7, a Cys-glutathione peroxidase missing a resolving Cys. ⺠The catalytic Cys is oxidized at a fast rate by hydroperoxides. ⺠GSH binds to the active site, but the release of the reduced enzyme is slow. ⺠GPx7 is competent for a fast oxidation of PDI. ⺠Kinetics suggest that physiological GSH regulates the oxidation of PDI by GPx7.
Keywords
TrxRResolving CysGPx7PCOOHRedoxinGPxsPDITrxGSSGGSHSECthioredoxin reductasethioredoxinROOHSelenocysteineRedox switchSynKineticsSynucleinendoplasmic reticulumHydroperoxidePhosphatidylcholine hydroperoxidePeroxideprotein disulfide isomerasePeroxiredoxinsreduced glutathioneoxidized glutathioneglutathione peroxidaseGlutathione peroxidases
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Valentina Bosello-Travain, Marcus Conrad, Giorgio Cozza, Alessandro Negro, Silvia Quartesan, Monica Rossetto, Antonella Roveri, Stefano Toppo, Fulvio Ursini, Mattia Zaccarin, Matilde Maiorino,