| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800676 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 10 Pages |
Abstract
⺠Most hematopoietic stem cells (HSCs) remain quiescent. ⺠Quiescence in HSCs is tightly regulated by many cell-cycle regulators. ⺠In most cases, ablation of such regulators in mouse HSCs results in loss of stemness. ⺠Future studies are required to translate the mouse knowledge to the clinical setting.
Keywords
HSCLatency-associated proteinchemokine (C-X-C motif) ligand 12TGF-βCKILLCLTBP-1TPOCXCL12SCFLAPHsc70CDKAPC/Canaphase-promoting complex/cyclosomeThrombopoietinHematopoietic stem celllarge latent complexUbiquitin–proteasome pathwaybone marrowcyclin-dependent kinase inhibitorNicheretinoblastoma proteinHeat shock cognate protein 70Cell cyclecyclin-dependent kinase
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Authors
Akinobu Matsumoto, Keiichi I. Nakayama,