| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800677 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 | 9 Pages |
Abstract
⺠Components of the DNA damage response (DDR) are critical in maintaining genomic integrity of ESCs and iPSCs. ⺠Failure to adequately repair DSBs can lead to genomic instability and cancer ⺠ESCs have unique mechanisms for maintaining a highly error-free form of DSB repair. ⺠DSB response may not be completely reprogrammed in all iPSCs. ⺠DDR presents a roadblock to high efficacy of iPSC generation during reprogramming.
Keywords
ataxia telangiectasia and Rad3-related protein53BP1PARP1P53-binding protein 1DNA-PKCtBPmDC1SSBRPAMRNIPSCNHEJNACDSBSCEATRXRCCCtIPDDRMEFataxia telangiectasia mutatedROSDNA damageionizing radiationSister chromatid exchangereplication protein AESCATMbreast cancer type 1 susceptibility proteinStem cellEmbryonic stem cellInduced pluripotent stem cellnon-homologous end joiningmouse embryonic fibroblastHomologous recombinationN-acetyl cysteineDNA-dependent protein kinasemediator of DNA damage checkpoint protein 1DNA damage responseC-terminal binding proteinpoly-ADP-ribose polymeraseBRCA1Reactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Pratik Nagaria, Carine Robert, Feyruz V. Rassool,