| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800698 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 10 Pages |
Abstract
⺠8-PN inhibits platelet aggregation induced by thrombin, collagen and U46619. ⺠8-PN impairs platelet adhesion to collagen. ⺠8-PN inhibits calcium mobilization and dense granule release. ⺠8-PN inhibits protein phosphorylation induced by thrombin and collagen. ⺠8-PN directly activates the inhibitory cGMP/PGK/VASP pathway in platelets.
Keywords
SGCPKG8-PNVASPODQpKa8-prenylnaringenin1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-oneBSAERK1/2MAPKThrombinVasodilator-stimulated phosphoproteinCyclic nucleotidessodium nitroprussideNitric oxideSignal transductionprotein kinase Aprotein kinase Gmitogen-activated protein kinasePlateletsSNPCollagenextracellular signal-regulated kinase
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Authors
Clara Di Vito, Alessandra Bertoni, Michela Nalin, Sara Sampietro, Manuela Zanfa, Fabiola Sinigaglia,