| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800699 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 10 Pages |
Abstract
⺠TMR-TAT mediated PCI is a promising delivery method but it is accompanied by cell death. ⺠TMR-TAT co-localizes with calcium containing endocytic vesicles in cells. ⺠Endosomal escape of TMR-TAT with light increases cytosolic calcium concentration. ⺠Calcium flux into the cytosol is followed by import of calcium into mitochondria. ⺠Release of calcium from endocytic vesicles is a causative factor of the cell death.
Keywords
DMFTrans-activator of transcriptionHOBtPTPRBCPDTEGTATMRDCMPDACPPPBSN-hydroxybenzotriazoleethylene glycol tetraacetic acidPermeability transition poreTATtriethylaminePhotodynamic therapyPhotochemical internalizationdimethylformamideDichloromethaneruthenium redPhosphate-buffered salineCell-penetrating peptideTEAcarboxytetramethylrhodamineCalciumred blood cell
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Authors
Nandhini Muthukrishnan, Gregory A. Johnson, Jongdoo Lim, Eric E. Simanek, Jean-Philippe Pellois,