| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800708 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 6 Pages |
Abstract
⺠Antifungal PUFAs increase unsaturation index of C. albicans and C. dubliniensis membranes. ⺠Antifungal PUFAs increase intracellular reactive oxygen species. ⺠Antifungal PUFAs decrease mitochondrial membrane potential, leading to apoptosis. ⺠We propose this as a mechanism of action of antifungal PUFAs.
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Authors
Vuyisile S. Thibane, Ruan Ells, Arno Hugo, Jacobus Albertyn, Walter J. Janse van Rensburg, Pieter W.J. Van Wyk, Johan L.F. Kock, Carolina H. Pohl,