| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10800714 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 10 Pages |
Abstract
⺠Mechanism of anticancer effects of anticancer dinuclear PtII complex was examined. ⺠The new PtII complex distorts DNA less extensively than conventional cisplatin. ⺠The new complex thermodynamically destabilizes DNA much less than cisplatin. ⺠Rationale behind improved antitumor effects of the new PtII complex is outlined.
Keywords
dNTPEMSAxeroderma pigmentosum group AXPAHmgFAASDMSPAADSCSDSPolyacrylamideDNA polymerase ηNERElectrophoretic mobility shift assayDNA repairDNA conformationdeoxyribonucleotide triphosphatenucleotide excision repaircalf thymusThermodynamic stabilitybase pairMelting TemperatureLinear dichroismdimethyl sulfatesodium dodecyl sulfatecisplatinAnticancerCross-linkPolηDifferential scanning calorimetryhigh-pressure liquid chromatographyHPLChigh mobility group
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Authors
Jarmila Mlcouskova, Jaroslav Malina, Vojtech Novohradsky, Jana Kasparkova, Seiji Komeda, Viktor Brabec,