Article ID Journal Published Year Pages File Type
10800717 Biochimica et Biophysica Acta (BBA) - General Subjects 2012 9 Pages PDF
Abstract
► Drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 was explored. ► For the mutations at 155 and 168, the main reason is the destroy of key salt bridges. ► For A156V mutation, the origin of drug resistance is the change of binding pocket.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: A computational study
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